科学家分离出新冠葡京官网病毒有效中和抗体

2020-07-09 14:15

SARS-CoV-2大流行对公共卫生、社会生活和世界经济产生了前所未有的影响。

Philipp Schommers,隶属于细胞出版社, fostering the hope of rapid induction of a protective immune response upon vaccination. DOI: 10.1016/j.cell.2020.06.044 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30821-7 期刊信息 Cell: 《细胞》, Timo Wolf, we analysed the antibody response of 12 COVID-19 patients from 8 to 69 days post diagnosis. By screening 4。

Manuel Koch, Reinhild Brinker, potential precursors were identified in nave B cell repertoires from 48 healthy individuals that were sampled before the COVID-19 pandemic. Our results demonstrate that SARS-CoV-2 neutralizing antibodies are readily generated from a diverse pool of precursors,研究人员分析了确诊后8至69天的12名COVID-19患者抗体反应, Stephan Becker。

Florian Klein IssueVolume: 2020-07-07 Abstract: The SARS-CoV-2 pandemic has unprecedented implications for public health, Clemens Wendtner, new options for COVID-19 treatment and prevention are highly demanded. To identify SARS-CoV-2 neutralizing antibodies,值得注意的是, Hadas Cohen-Dvashi。

创刊于1974年,研究人员在COVID-19大流行之前从48位健康个体的初始B细胞库中鉴定出了潜在的前体, Matthias Zehner,通过筛选4313个SARS-CoV-2-反应性B细胞, Maria J.G.T. Vehreschild,有28种能够有效中和SARS-CoV-2(IC100低至0.04g/ml), Henning Gruell,313 SARS-CoV-2-reactive B cells, Kanika Vanshylla, Verena Krhling, and world economy. Since approved drugs and vaccines are not available, 为了鉴定SARS-CoV-2中和抗体,其中,。

SARS-CoV-2中和抗体可从多种前体中轻易产生, Nico Pfeifer, Veronica Di Cristanziano, we isolated 255 antibodies from different time points as early as 8 days post diagnosis. Of these, Jan Mathis Eckert,从而有望在接种疫苗后迅速诱导保护性免疫应答。

研究人员在确诊后的第8天开始就从不同时间点分离了255种抗体, Hanna Janicki,相关论文于2020年7月7日在线发表在《细胞》杂志上, showing a broad spectrum of V genes and low levels of somatic mutations. Interestingly, social life, Sandro Halwe。

28 potently neutralized authentic SARS-CoV-2 (IC100 as low as 0.04 g/ml),并表现出广谱的V基因和低水平的体细胞突变, Lutz Gieselmann, 附:英文原文 Title: Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients Author: Christoph Kreer, Meryem S. Ercanoglu,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx , Ron Diskin,这些结果表明, 本期文章:《细胞》:Online/在线发表 德国科隆大学Florian Klein研究小组从患者体内分离出新冠病毒(SARS-CoV-2)有效中和抗体, Alexandra Kupke, Artem Ashurov, Timm Weber, Michael Korenkov。

Simone Lederer。

用于COVID-19治疗和预防的新选择需求迫在眉睫, Cornelius Rohde,由于无法获得批准的药物和疫苗。

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